Germline mutations of BRCA2 were examined in 20 Japanese breast cancer families without BRCA1 mutations, including one demonstrating cancer development in a male. Three different mutations, resulting in truncation of the BRCA2 protein, were detected in 3 different families. They were 9474insA (exon
BRCA2 germline mutations in male breast cancer patients in the Polish population
โ Scribed by Eliza Kwiatkowska; Marek Teresiak; Katarzyna M. Lamperska; Aldona Karczewska; Danuta Breborowicz; Malgorzata Stawicka; Dariusz Godlewski; Wlodzimierz J. Krzyzosiak; Andrzej Mackiewicz
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 24 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1059-7794
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Germline mutations in the BRCA1 and BRCA2 genes account for the majority of high-risk breast/ovarian cancer families, depending on the population studied. Previously, BRCA1 mutations were described in women from Western Poland. To further characterize the spectrum of BRCA1 mutations and the impact o
We have investigated the impact of BRACA1 and BRACA2 mutations that were frequently identified among Hungarian high-risk breast-ovarian cancer families (Ramus et al., 1997b, AJHG), on the development of breast and ovarian cancer in the general Hungarian population. The prevalence of 3 BRCA1 mutation