The presence of genomic rearrangements of the BRCA1 gene in breast and/or ovarian cancer families has been intensively investigated in patients from various countries over the last years. A number of different rearrangements have been reported by several studies that clearly document the involvement
BRCA1/BRCA2rearrangements andCHEK2common mutations are infrequent in Italian male breast cancer cases
✍ Scribed by Mario Falchetti; Ramona Lupi; Piera Rizzolo; Ketty Ceccarelli; Ines Zanna; Valentina Calò; Stefania Tommasi; Giovanna Masala; Angelo Paradiso; Alberto Gulino; Giuseppe Giannini; Antonio Russo; Domenico Palli; Laura Ottini
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 223 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
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The entire coding regions of BRCA1 and BRCA2 were screened for mutations by heteroduplex analysis in 51 Mexican breast cancer patients. One BRCA1 and one BRCA2 truncating mutation each was identified in the group of 32 (6%) early-onset breast cancer patients (< or =35 years). Besides these two likel
Male breast cancer (MBC) is a rare disease and, because of its rarity, its etiology is poorly understood. However, germ-line mutations in breast cancer susceptibility gene BRCA2 are known to predispose to MBC. 1 Male carriers of BRCA2 mutations have an 80-100 times high risk for the development of b