BRCA1-positive breast cancers in young women from Poland
✍ Scribed by J. Lubiński; B. Górski; T. Huzarski; T. Byrski; J. Gronwald; P. Serrano-Fernández; W. Domagała; M. Chosia; M. Uciński; E. Grzybowska; D. Lange; B. Mąka; A. Mackiewicz; A. Karczewska; J. Bręborowicz; K. Lamperska; M. Stawicka; S. Gozdecka-Grodecka; M. Bębenek; D. Sorokin; A. Wojnar; O. Haus; J. Sir; T. Mierzwa; S. Niepsuj; K. Gugała; S. Góźdź; J. Sygut; B. Kozak-Klonowska; B. Musiatowicz; M. Posmyk; R. Kordek; M. Morawiec; O. Zambrano; B. Waśko; L. Fudali; J. Skręt; D. Surdyka; K. Urbański; J. Mituś; J. Ryś; M. Szwiec; A. Rozmiarek; I. Dziuba; P. Wandzel; R. Wiśniowski; C. Szczylik; A. Kozak; W. Kozłowski; S.A. Narod
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 212 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0167-6806
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Sixty high-risk breast and/or ovarian cancer families from North-Eastern Poland were screened for germline mutations in BRCA1 (MIM# 113705) and BRCA2 (MIM# 600185), using a combination of protein truncation test, denaturing high-performance liquid chromatography and direct sequencing. Sixteen (27%)
## Abstract Previous studies have shown that breast cancers have more aggressive pathologic features in young women. In order to examine genetic alterations associated with early‐onset breast cancer, 31 patients with no known family history, aged 26–35 years at diagnosis, were examined for loss of