Incidence of breast cancer in Indian women is not as high as in Western countries, nonetheless age-adjusted incidence rates (AAR) have risen from 17.9 to 24.9 per 100,000 from 1965 to 1985. Although these rates are still approximately one quarter to one third of incidence rates in North America and
Analysis of BRCA1 involvement in breast cancer in Indian women
β Scribed by P. H. Pestonjamasp; I. Mittra
- Publisher
- Indian Academy of Sciences
- Year
- 2000
- Tongue
- English
- Weight
- 49 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0250-5991
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Family pedigrees of Oklahoma Indian women with a history of breast cancer were developed with special reference to age at onset, cancer pathology (if known), age of death, cause of death, and blood quantum as recorded by the Bureau of Indian Affairs (BIA) Certificate of Degree of Indian Blood (CDIB)
The two major hereditary breast/ovarian cancer predisposition tumor suppressor genes, BRCA1 and BRCA2 that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are altered, or mutated in the germline. However, little is known abo