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BRCA1 mutations found in archived early onset breast tumours

✍ Scribed by A.M. Garvin; U. Eppenberger; H. Müller; S. Eppenberger-Castori; R.J. Scott

Book ID
117663699
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
359 KB
Volume
33
Category
Article
ISSN
0959-8049

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✍ Fergus J. Couch; Barbara L. Weber 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 1009 KB

Mutations in the familial early-onset breast cancer gene (BRCA1) account for approximately 2-5% of all breast cancer cases (Easton et al., 1993). Since the isolation of the BRCA1 gene in 1994, many mutations have been identified. We report here a total of 254 BRCA1 mutations, 132 (52%) of which are