Impact of BRCA1 mutation on survival after early onset breast cancer
✍ Scribed by T Huzarski, T Byrski, J Gronwald, B Górski…
- Book ID
- 120698998
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 84 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1897-4287
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Mutations in the familial early-onset breast cancer gene (BRCA1) account for approximately 2-5% of all breast cancer cases (Easton et al., 1993). Since the isolation of the BRCA1 gene in 1994, many mutations have been identified. We report here a total of 254 BRCA1 mutations, 132 (52%) of which are
The entire coding regions of BRCA1 and BRCA2 were screened for mutations by heteroduplex analysis in 51 Mexican breast cancer patients. One BRCA1 and one BRCA2 truncating mutation each was identified in the group of 32 (6%) early-onset breast cancer patients (< or =35 years). Besides these two likel