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BRCA1, a gene involved in inherited predisposition to breast and ovarian cancer

โœ Scribed by Jean Feunteun; Gilbert M. Lenoir

Book ID
113312478
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
413 KB
Volume
1242
Category
Article
ISSN
0304-419X

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A total of 283 epithelial ovarian cancer families from the United Kingdom (UK) and the United States (US) were screened for coding sequence changes and large genomic alterations (rearrangements and deletions) in the BRCA1 and BRCA2 genes. Deleterious BRCA1 mutations were identified in 104 families (