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BRCA1 185delAG mutation in a non-Ashkenazi Jewish woman with early-onset breast and ovarian cancer

✍ Scribed by J. Menczer; Livia Theodor; Eitan Friedman


Book ID
113984524
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
113 KB
Volume
176
Category
Article
ISSN
1097-6868

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A low frequency of non-founder BRCA1 mut
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The 185delAG and 5382insC founder mutations account for the majority of mutations identified in BRCA1 in Ashkenazi Jewish breast and breast-ovarian cancer families. Few non-founder BRCA1 mutations have been identified to date in these families. We initially screened a panel of 245 Ashkenazi Jewish b