๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Brainstem pathology in spasmodic dysphonia

โœ Scribed by Kristina Simonyan; Christy L. Ludlow; Alexander O. Vortmeyer

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
157 KB
Volume
120
Category
Article
ISSN
0023-852X

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

Spasmodic dysphonia (SD) is a primary focal dystonia of unknown pathophysiology, characterized by involuntary spasms in the laryngeal muscles during speech production. We examined two rare cases of postmortem brainstem tissue from SD patients compared to four controls. In the SD patients, small clusters of inflammation were found in the reticular formation surrounding solitary tract, spinal trigeminal, and ambigual nuclei, inferior olive, and pyramids. Mild neuronal degeneration and depigmentation were observed in the substantia nigra and locus coeruleus. No abnormal protein accumulations and no demyelination or axonal degeneration were found. These neuropathological findings may provide insights into the pathophysiology of SD. Laryngoscope, 2010

๐Ÿ“œ SIMILAR VOLUMES

Perioral reflexes in orofacial dyskinesi
Perioral reflexes in orofacial dyskinesia and spasmodic dysphonia
โœ Dr. Helge Topka; Dr. Mark Hallett ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 480 KB

In order to assess the clinical utility of trigemino-facial reflexes in lower facial muscles, we studied perioral reflexes to mechanical and electrical stimulation in 13 patients with spasmodic dysphonia and orofacial dyskinesia and in 7 healthy subjects. Mechanical stimulation of the upper lip of a

Normalization of voice in spasmodic dysp
Normalization of voice in spasmodic dysphonia during transient global amnesia
โœ Asha Kishore; Anthony E. Lang ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 42 KB

## Abstract We report on the case of a 69โ€yearโ€old woman with Parkinson's disease and longโ€standing history of spasmodic dysphonia that reversed during an episode of transient global amnesia (TGA). To our knowledge, this phenomenon has not been reported before. We suggest possible mechanisms by whi

Safety and efficacy of botulinum toxin t
Safety and efficacy of botulinum toxin type B (Myobloc) in adductor spasmodic dysphonia
โœ Charles H. Adler; Stephen F. Bansberg; Kari Krein-Jones; Joseph G. Hentz ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 68 KB

## Abstract This singleโ€site, openโ€label, doseโ€finding study evaluated the safety and efficacy of botulinum toxin type B (BoNTโ€B; Myobloc) for the treatment of adductor spasmodic dysphonia (AdSD) in 13 patients. Three patients received a total of 50 U (25 U per vocal fold); the same three subsequen

Spasmodic dysphonia in a patient with th
Spasmodic dysphonia in a patient with the A to G transition at nucleotide 8344 in mitochondrial DNA
โœ Ying Peng; Roger Crumley; John M. Ringman ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 57 KB

## Abstract Dystonia has been described in various diseases affecting mitochondrial function but spasmodic dysphonia, a form of focal dystonia, has not. We present a patient with action myoclonus affecting the hands and arms who carried the most common mutation in mitochondrial DNA causing the myoc

The prevalence of laryngeal pathology in
The prevalence of laryngeal pathology in a treatment-seeking population with dysphonia
โœ Evelyne Van Houtte; Kristiane Van Lierde; Evelien D'Haeseleer; Sofie Claeys ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 224 KB

## Abstract ## Objectives/Hypothesis. This article describes the prevalence of laryngeal pathology in a treatmentโ€seeking population with dysphonia in the Flemish part of Belgium. ## Study Design. Retrospective investigation. ## Methods. During a period of 5 years (2004โ€“2008), data were collec