Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy
β Scribed by Joseph A Nicolazzo; Jessica A Steuten; Susan A Charman; Nerida Taylor; Philip J Davies; Steven Petrou
- Book ID
- 108940682
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 175 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0305-1870
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Involvement of nitric oxide (NO) in the regulation of the epileptic activity was studied in WAG/Rij rats, a genetic model of absence epilepsy. I.c.v. administration of NO donors: S-nitroso-Nacetylpenicillamine (SNAP, 0.5 and 5 pg), 3-morpholino-sydnonimine (SIN-1, 0.5 and 5 pg) or sodium nitroprussi
## Abstract We suggest that a dysregulation of energy metabolism in the brain of genetic absence epilepsy rats from Strasbourg (GAERS) could create a specific cerebral environment that would favor the expression of spikeβandβwave discharges (SWD) in the thalamocortical loop, largely dependent on gl