Thalamic NMDA transmission in a genetic model of absence epilepsy in rats
β Scribed by C. Koerner; L. Danober; A. Boehrer; C. Marescaux; M. Vergnes
- Book ID
- 108022899
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 664 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0920-1211
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π SIMILAR VOLUMES
Involvement of nitric oxide (NO) in the regulation of the epileptic activity was studied in WAG/Rij rats, a genetic model of absence epilepsy. I.c.v. administration of NO donors: S-nitroso-Nacetylpenicillamine (SNAP, 0.5 and 5 pg), 3-morpholino-sydnonimine (SIN-1, 0.5 and 5 pg) or sodium nitroprussi
The WAG/Rij rat strain is characterized in its EEG by the manifestation of spike-wave discharges which resemble in their spontaneous appearance and pharmacological sensitivity the absence epilepsy observed in humans. In order to test the hypothesis whether cellular intrinsic membrane and/or synaptic