There is growing interest in investigating the role of subtle changes in blood–brain barrier (BBB) function in common neurological disorders and the possible use of imaging techniques to assess these abnormalities. Some studies have used dynamic contrast-enhanced MR imaging (DCE-MRI) and these have
Brain redox imaging using blood–brain barrier-permeable nitroxide MRI contrast agent
✍ Scribed by Hyodo, Fuminori; Chuang, Kai-Hsiang; Goloshevsky, Artem G; Sulima, Agnieszka; Griffiths, Gary L; Mitchell, James B; Koretsky, Alan P; Krishna, Murali C
- Book ID
- 109871075
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 485 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0271-678X
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## Abstract Breakdown of the blood‐brain barrier (BBB), occurring in many neurological diseases, has been difficult to measure noninvasively in humans. Dynamic contrast‐enhanced magnetic resonance imaging measures BBB permeability. However, important technical challenges remain and normative data f
## Abstract ## Purpose: To design a more accurate and reproducible technique for the measurement of blood–brain barrier (BBB) permeability in gadolinium‐enhancing multiple sclerosis (MS) lesions. ## Materials and Methods: Four MS patients were scanned using a new dynamic contrast‐enhanced (DCE)‐