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BRAIN PENETRATION AND ORGAN DISTRIBUTION OF TROSPIUM CHLORIDE AND OXYBUTYNIN: THE ROLE OF THE MULTIDRUG RESISTANCE TRANSPORTER MDR1

✍ Scribed by Geyer, Joachim; Gavrilova, Olga; Petzinger, Ernst

Book ID
123360488
Publisher
Lippincott Williams and Wilkins
Year
2008
Tongue
English
Weight
124 KB
Volume
179
Category
Article
ISSN
0022-5347

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Previous in vitro studies evaluating the permeability of enaminones suggested that their bloodΒ±brain barrier (BBB) transport might be inΒ―uenced by the presence of an efΒ―ux mechanism. Therefore, transport mechanisms responsible for these anticonvulsants across the BBB were examined. The transport of