𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Brain Ia antigens have a bone marrow origin

✍ Scribed by Jenny P.-Y. Ting; Douglas F. Nixon; Leslie P. Weiner; Jeffrey A. Frelinger

Book ID
104741127
Publisher
Springer-Verlag
Year
1983
Tongue
English
Weight
436 KB
Volume
17
Category
Article
ISSN
0093-7711

No coin nor oath required. For personal study only.

✦ Synopsis

Our results, using radiation-induced bone marrow chimeras, demonstrate that the Ia antigen found in the brains of such animals is produced by cells having precursors in the bone marrow. These cells are not immediately blood borne since no IgM is detected in these brains. This rules out the obvious possibility of B-lymphocyte contamination as the source of Ia in the brain cell preparations. It thus appears that the central nervous system, like many other nonlymphoid organs, has a source of Ia-positive cells that are derived from bone marrow precursors.

πŸ“œ SIMILAR VOLUMES

Many cells in rat bone marrow have cell-
Many cells in rat bone marrow have cell-surface Thy-1 antigen
✍ A. F. Williams πŸ“‚ Article πŸ“… 1976 πŸ› John Wiley and Sons 🌐 English βš– 337 KB

## Abstract Thy‐1.1 and Thy‐1 xenoantigenic determinants were detected at the cell surface of many rat bone marrow cells. The absorptive capacity of bone marrow cells was 6–10 % of that of thymocytes for Thy‐1 antigenic determinants, and 30–45 % of rat bone marrow cells were specifically labeled wi