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Brain drug targeting: a computational approach for overcoming blood–brain barrier

✍ Scribed by Ahmad Reza Mehdipour; Mehrdad Hamidi


Book ID
113569031
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
249 KB
Volume
14
Category
Article
ISSN
1359-6446

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## Abstract Glial‐derived neurotrophic factor (GDNF) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson's disease, stroke, and motor neuron disease. However, GDNF does not cross the blood–brain barrier (BBB). Human GDNF was re‐engineered by fusion of the mature GDNF prote