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Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics

โœ Scribed by Lisa A Howard; Sharon Miksys; Ewa Hoffmann; Deborah Mash; Rachel F Tyndale


Book ID
110007696
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
341 KB
Volume
138
Category
Article
ISSN
0007-1188

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Induction of CYP2E1 by ethanol is one pathway through which ethanol generates oxidative stress. Nrf2 is a transcription factor that regulates important antioxidant and phase II detoxification genes. Nrf2 induction by CYP2E1 and its importance in the adaptive response to increased oxidative stress ca