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BRAF,KRAS, and Phosphatidylinositol 3-Kinase in the Management of Metastatic Colorectal Cancer

✍ Scribed by Coutinho, Anelisa K.; Prolla, Gabriel; Weschenfelder, Rui

Book ID
120180999
Publisher
Current Science Inc.
Year
2013
Tongue
English
Weight
308 KB
Volume
9
Category
Article
ISSN
1556-3790

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## Abstract Mutational analysis of __KRAS__ codons 12 and 13 is standard for patients with metastatic colorectal cancer since mutations in these codons predict lack of response to anti‐EGFR therapies. However, even among patients whose tumors are wildtype for __KRAS__ codons 12 and 13, only a subse