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BRAF inhibition and beyond in advanced melanoma

โœ Scribed by Kim Margolin


Book ID
117310526
Publisher
The Lancet
Year
2012
Tongue
English
Weight
752 KB
Volume
380
Category
Article
ISSN
0140-6736

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## Background Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with da braf e nib, a selective BRAF inhibitor, and trametinib, a