๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

BRAF and MEK inhibitors in BRAF-mutant melanoma

โœ Scribed by Sharan Prakash Sharma

Book ID
119609078
Publisher
The Lancet
Year
2012
Tongue
English
Weight
126 KB
Volume
13
Category
Article
ISSN
1470-2045

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Combined BRAF and MEK Inhibition in Mela
Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations
โœ Flaherty, Keith T.; Infante, Jeffery R.; Daud, Adil; Gonzalez, Rene; Kefford, Ri ๐Ÿ“‚ Article ๐Ÿ“… 2012 ๐Ÿ› Massachusetts Medical Society ๐ŸŒ English โš– 528 KB

## Background Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with da braf e nib, a selective BRAF inhibitor, and trametinib, a