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BRAF and c-kit gene copy number in mutation-positive malignant melanoma

โœ Scribed by Carlynn Willmore-Payne; Joseph A. Holden; Sharon Hirschowitz; Lester J. Layfield


Book ID
116534139
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
524 KB
Volume
37
Category
Article
ISSN
1532-8392

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## Abstract A majority of malignant melanomas harbor an oncogenic mutation in either __BRAF__ or __NRAS__. If __BRAF__ and __NRAS__ transform melanoma cells by a similar mechanism, then additional genetic aberrations would be similar (or random). Alternatively, distinct mutationโ€associated changes