✦ LIBER ✦

BRAF alterations are associated with complex mutational profiles in malignant melanoma

✍ Scribed by Daniotti, Maria; Oggionni, Maria; Ranzani, Tiziana; Vallacchi, Viviana; Campi, Valentina; Di Stasi, Delia; Torre, Gabriella Della; Perrone, Federica; Luoni, Chiara; Suardi, Simona

Book ID: 110068850
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 308 KB
Volume: 23
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1207780

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Distinct patterns of DNA copy number alt

Distinct patterns of DNA copy number alterations associate with BRAF mutations in melanomas and melanoma-derived cell lines

✍ J. Greshock; K. Nathanson; A. Medina; M. R. Ward; M. Herlyn; B. L. Weber; T. Z. 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 301 KB 👁 1 views

## Abstract A majority of malignant melanomas harbor an oncogenic mutation in either __BRAF__ or __NRAS__. If __BRAF__ and __NRAS__ transform melanoma cells by a similar mechanism, then additional genetic aberrations would be similar (or random). Alternatively, distinct mutation‐associated changes

EGFR gene copy number alterations in pri

EGFR gene copy number alterations in primary cutaneous malignant melanomas are associated with poor prognosis

✍ Zsuzsa Rákosy; Laura Vízkeleti; Szilvia Ecsedi; Zoltán Vokó; Ágnes Bégány; Márk 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 306 KB

## Abstract Copy number alterations of the epidermal growth factor receptor (__EGFR__) gene have been extensively analyzed in different cancers, but no data are available for primary malignant melanoma. The aim of the present study was to simultaneously investigate the __EGFR__ gene and chromosome

Malignant melanoma in a woman with LEOPA

Malignant melanoma in a woman with LEOPARD syndrome: identification of a germline PTPN11 mutation and a somatic BRAF mutation

✍ M. Seishima; Y. Mizutani; Y. Shibuya; C. Arakawa; R. Yoshida; T. Ogata 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 545 KB

Mutations of BRAF are associated with ex

Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas

✍ Koji Koinuma; Kazuhisa Shitoh; Yasuyuki Miyakura; Taiji Furukawa; Yoshihiro Yama 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 175 KB 👁 2 views

## Abstract Activating mutations of __BRAF__ have been frequently observed in microsatellite unstable (MSI^+^) colorectal carcinomas (CRCs), in which mutations of __BRAF__ and __KRAS__ are mutually exclusive. Previously, we reported that hypermethylation of __hMLH1__ might play an important role in

Activating BRAF and N-Ras mutations in s

Activating BRAF and N-Ras mutations in sporadic primary melanomas: an inverse association with allelic loss on chromosome 9

✍ Kumar, Rajiv; Angelini, Sabrina; Hemminki, Kari 📂 Article 📅 2003 🏛 Nature Publishing Group 🌐 English ⚖ 199 KB

Characterization of candidate gene copy

Characterization of candidate gene copy number alterations in the 11q13 region along with BRAF and NRAS mutations in human melanoma

✍ Lázár, Viktória; Ecsedi, Szilvia; Szöllősi, Attila G; Tóth, Réka; Vízkeleti, Lau 📂 Article 📅 2009 🏛 Nature Publishing Group 🌐 English ⚖ 345 KB