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Both the precursors and the effectors of human lymphokine-activated killer (LAK) cells may belong to T lymphocytes

✍ Scribed by Maria Cristina Mingari; Daniela Pende; Raffaella Cozzani; Annalisa Merli; Alessandro Poggi; Silvano Ferrini; Lorenzo Moretta


Publisher
Springer
Year
1986
Tongue
English
Weight
275 KB
Volume
16
Category
Article
ISSN
0940-5437

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The cell lineage of the lymphokine-activated killer (LAK) cells has been reinvestigated. Both T and non-T cells, isolated on the basis of rosette formation with sheep erythrocytes (E), generated LAK activity after 3-4 days of culture in recombinant interleukin 2 (rIL 2) in 8 different individuals te

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## Lymphokine -activated killer (LAK) activity was first analyzed on PBL populations fractionated on the basis of the expression of TI1 or T3 antigen. LAK cell precursors were found to be present in both T I I + and TI Ipopulations, but only in the T3cell fraction. The generation of LAK activity i

The Lyt phenotype of a long-term allospe
✍ Susan L. Swain; Gunther Dennert; Susan Wormsley; Richard W. Dutton πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 687 KB

## Abstract The relationship between surface antigen expression and function in the long‐term allospecific T cell line C.C3.11.75 was examined by flow microfluorometry, antiserum plus complement depletion and cell sorting. T cells of the line expressed Lyt‐1, but little or no Lyt‐2 antigens. Prolif