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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

✍ Scribed by Galloway, Denise A.; Kiyono, Tohru; Foster, Scott A.; Koop, Jenn I.; McDougall, James K.; Klingelhutz, Aloysius J.


Book ID
109683834
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
425 KB
Volume
396
Category
Article
ISSN
0028-0836

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## Abstract Prostate cancer is a major cause of cancer death among male population. Therefore, development of appropriate model systems is critical for understanding the molecular basis of prostate cancer progression. In this study, introduction of human telomerase (hTERT) into normal human prostat