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Bone targeted drugs 2. synthesis of estrogens with hydroxyapatite affinity

✍ Scribed by Timothy M. Willson; Brad R. Henke; Tanya M. Momtahen; Deanna T. Garrison; Linda B. Moore; Nora G. Geddie; Philip G. Baer

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 189 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00165-5

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✦ Synopsis

The utility of the bone targeting 4-carboxy-3-hydroxy-l,2-pyrazole heterocycle was tested by the synthesis of hybrids with the non-steroidal estrogen hexestrol. Compounds 1 and 2 demonstrated significant hydroxyapatite affinity, while maintaining weak estrogenic activity in whole cell assays.

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