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Bone targeted drugs 1. Identification of heterocycles with hydroxyapatite affinity

โœ Scribed by Timothy M. Willson; Paul S. Charifson; Anthony D. Baxter; Nora G. Geddie

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
204 KB
Volume
6
Category
Article
ISSN
0960-894X

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๐Ÿ“œ SIMILAR VOLUMES

Bone targeted drugs 2. synthesis of estr
Bone targeted drugs 2. synthesis of estrogens with hydroxyapatite affinity
โœ Timothy M. Willson; Brad R. Henke; Tanya M. Momtahen; Deanna T. Garrison; Linda ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 189 KB

The utility of the bone targeting 4-carboxy-3-hydroxy-l,2-pyrazole heterocycle was tested by the synthesis of hybrids with the non-steroidal estrogen hexestrol. Compounds 1 and 2 demonstrated significant hydroxyapatite affinity, while maintaining weak estrogenic activity in whole cell assays.