BMP4/NOGGIN contribute to abnormal neurogenesis in the adult hippocampal of APPSWE/PS1 e9 transgenic mouse model of Alzheimer's disease
β Scribed by Tang, Jun
- Book ID
- 122989170
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 56 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1552-5260
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## Abstract Alterations in hippocampal cell proliferation have been identified in transgenic (tg) mouse models of Alzheimer's disease (AD); however, relatively little is known about the underlying mechanisms. Previously, we have demonstrated that endogenous level of BMP4 in the dentate gyrus (DG) a
## Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with senile Ξ²βamyloid (AΞ²) plaques and cognitive decline. Neurogenesis in the adult hippocampus is implicated in regulating learning and memory, and is increased in human postmortem brain of AD patients. Howe