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Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

✍ Scribed by Shlosberg, Dan; Benifla, Mony; Kaufer, Daniela; Friedman, Alon

Book ID
111694536
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
308 KB
Volume
6
Category
Article
ISSN
1759-4758

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The family of calcium-activated neutral proteases, calpains, appears to play a key role in neuropathologic events following traumatic brain injury (TBI). Neuronal calpain activation has been observed within minutes to hours after either contusive or diffuse brain trauma in animals, suggesting that c