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Blood velocity assessment using 3D bright-blood time-resolved magnetic resonance angiography

✍ Scribed by Sylvain Miraux; Jean-Michel Franconi; Eric Thiaudière

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
276 KB
Volume
56
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Blood velocity is a functional parameter that is not easily assessed noninvasively, especially in small animals. A new noninvasive method that uses magnetic resonance angiography (MRA) to measure blood flows is proposed. This method is based on the time‐of‐flight (TOF) phenomenon. By initially suppressing the signal from the stationary spins in the area of interest, it is possible to sequentially visualize only the signal from the moving spins entering a given volume. With this method, 3D cine images of the blood flow can be generated by positive contrast, with unparalleled spatial (<200 μm) and temporal resolutions (<10 ms/image). As a result, it is possible to measure flow in sinuous paths. The present method was applied in vivo to measure the blood velocity in mouse carotid arteries. Because of its robustness and simplicity of implementation, this method has numerous potential applications for fundamental studies in small animal models. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.

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