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Blood oxygenation dependence of t1 and t2 in the isolated, perfused rabbit heart at 4.7t

✍ Scribed by Michael K. Atalay; Scott B. Reeder; Elias A. Zerhouni; John R. Forder

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
673 KB
Volume
34
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

An MR line scan protocol has been used to measure relaxation parameters (T~1~ and T~2~) in isolated, blood perfused rabbit hearts at various blood oxygenations. Hearts were retro‐gradely perfused at 37°C with a cardioplegic solution (modified St. Thomas' solution) containing sheep red blood cells and adenosine (1 m__M__) to maximally vasodilate the coronary vascular bed. Arresting the hearts eliminated motion complications and minimized arteriovenous oxygenation differences. The authors have found that under conditions of stable flow, there is a strong correlation between T~2~ in myocardial septa and hemoglobin (Hb) saturation, while tissue T~1~ is virtually independent of blood oxygenation. These effects are believed to be due to the paramagnetic agent deoxyhemoglobin.

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