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Blocking IL-1α but not IL-1β increases susceptibility to chronic Mycobacterium tuberculosis infection in mice

✍ Scribed by Reto Guler; Suraj P. Parihar; Gunther Spohn; Pål Johansen; Frank Brombacher; Martin F. Bachmann

Book ID
116963193
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
913 KB
Volume
29
Category
Article
ISSN
0264-410X

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IL-10 regulates the balance of an immune response between pathogen clearance and immunopathology. We show here that __Mycobacterium tuberculosis__ (__Mtb__) infection in the absence of IL-10 (IL-10^−/−^ mice) results in reduced bacterial loads in the lung. This reduction was preceded by an accelerat