Blockade of long-term potentiation in the dendate gyrus of freely moving rats by the glutamic acid antagonist GDEE
✍ Scribed by Manfred Krug; Rudolf Bro¨demann; Tilmann Ott
- Book ID
- 118867428
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 513 KB
- Volume
- 249
- Category
- Article
- ISSN
- 0006-8993
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The ability of the perforant path/dentate granule cell synapse of the hippocampal formation to establish and maintain enhanced levels of synaptic transmission in response to tetanization (longterm potentiation, LTP) was investigated in freely moving rats at 15, 30, and 90 days of age. Measures of 1)
Long-term potentiation (LTP) or long-term depression (LTD) can be produced in the dentate gyrus (DG) of the hippocampus with high-or low-frequency stimulation trains, respectively. Although LTP can be elicited in a variety of preparations, we know of no reports of LTD unaccompanied by seizure activi