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Blockade of Kv1.3 Potassium Channels Inhibits Granzyme B Production in Human Cd8+ T Lymphocytes

✍ Scribed by Lina Hu; Katherine Mullen; Rameeza Allie; Peter Calabresi


Book ID
113539301
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
38 KB
Volume
119
Category
Article
ISSN
1090-2341

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## Abstract Using the whole-cell patch-clamp technique, we investigated the influence of 8-prenylnaringenin on the activity of the voltage-gated Kv1.3 potassium channels in the human leukemic T lymphocyte cell line Jurkat. 8-prenylnaringenin is a potent plant-derived phytoestrogen that has been fou