✦ LIBER ✦

Blockade of colony stimulating factor-1 (CSF-1) leads to inhibition of DSS-induced colitis

✍ Scribed by Diane Marshall; James Cameron; Daniel Lightwood; Alastair D.G. Lawson

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 623 KB
Volume: 13
Category: Article
ISSN: 1078-0998
DOI: 10.1002/ibd.20055

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

Intestinal inflammation associated with inflammatory bowel disease (ibd) is typically characterized by an inflammatory cell infiltrate and pro-inflammatory cytokine production. of particular interest, the frequency of colony stimulating factor-1 (csf-l)-expressing cells is increased in active lesions. in this study, we have investigated the role of csf-1 in mucosal inflammation, using a murine model of colitis induced by dextran sulfate sodium (dss).

Methods:

A neutralizing anti-csf-1 antibody was administered to balb/c mice that received dss in their drinking water. signs of colitis, such as clinical disease score, cellular infiltrate, and cytokine production, were assessed.

Results:

Administration of a neutralizing anti-csf-1 antibody significantly inhibited dss-induced colitis. clinical symptoms, such as weight loss and the appearance of diarrhea or fecal blood, were reduced by csf-1 blockade; histologic scores were also improved. the cellular infiltrate of macrophages and t cells was inhibited and a trend toward reduced production of pro-inflammatory cytokines was noted.

Conclusions:

This is the first study to demonstrate that csf-1 plays an important role in mediating intestinal mucosal inflammation and therefore may prove to be an attractive therapeutic target for intestinal diseases such as inflammatory bowel disease.

📜 SIMILAR VOLUMES

Tumor-promoting phorbol esters inhibit t

Tumor-promoting phorbol esters inhibit the binding of colony-stimulating factor (CSF-1) to murine peritoneal exudate macrophages

✍ Ben D.-M. Chen; Hsiu-San Lin; Shin Hsu 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 624 KB

## Abstract L‐cell colony‐stimulating factor (CSF‐1) is a sialoglycoprotein of molecular weight 70,000 daltons that specifically stimulates macrophage colony formation by single committed cells from normal mouse bone marrow and by various classes of more differentiated tissue‐derived mononuclear ph

Identification of tyrosine-phosphorylate

Identification of tyrosine-phosphorylated colony-stimulating factor 1 (CSF-1) receptor and a 56-kilodalton protein phosphorylated in intact human cells in response to CSF-1

✍ Richard D. Huhn; Mary Elizabeth Cicione; A. Raymond Frackelton Jr. 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 599 KB

Colony-stimulating factor 1 (CSF-1) selectively supports the survival, proliferation, and maturation of hemopoietic cells of the monocytehacrophage lineage. Although the cellular receptor for CSF-1, (the c-fms protein) is a protein-tyrosine kinase activated by the binding of CFS-I, the role of phosp

Gamma interferon induces expression of M

Gamma interferon induces expression of Mad1 gene in macrophage, which inhibits colony-stimulating factor-1–dependent mitogenesis

✍ Arunangsu Dey; Leopold Kim; Wei Li 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 162 KB

Gamma interferon (IFN-gamma) has long been known as an antiproliferative cytokine. The mechanism of its action, however, remains elusive. Monocytes and macrophages are primary targets of IFN-gamma. To understand the antiproliferative signaling of IFNgamma, we studied the effect of IFNgamma on expres

The nature of 12-O-tetradecanoylphorbol-

The nature of 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated hemopoiesis, colony stimulating factor (CSF) requirement for colony formation, and the effect of TPA on [125I]CSF-1 binding to macrophages

✍ L. J. Guilbert; D. J. Nelson; J. A. Hamilton; N. Williams 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 770 KB

1,25-dihydroxycholecalciferol-induced di

1,25-dihydroxycholecalciferol-induced differentiation of myelomonocytic leukemic cells unresponsive to colony stimulating factors and phorbol esters

✍ Florence Bettens; Erich Schlick; William Farrar; Francis Ruscetti 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 779 KB

Growth regulation of the AML-193 leukemi

Growth regulation of the AML-193 leukemic cell line: Evidence for autocrine production of granulocyte-macrophage colony-stimulating factor (GM-CSF), and inhibition of GM-CSF-dependent cell proliferation by interleukin-1 (IL-1) and tumor necrosis factor (tnfα)

✍ Vincent Kindler; John Shields; Dominique Ayer; Gonzalo J. Mazzei 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 583 KB

The human leukemic cell line AML-193 was tested for its proliferative response to endogenously produced autocrine factors and to a variety of cytokines and colony-stimulating factors. Cells grown in the absence of GM-CSF incorporated tritiated thymidine, and this was partially reversed by adding neu