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Bisphenol A and Its Analogues Activate Human Pregnane X Receptor

✍ Scribed by Sui, Yipeng; Ai, Ni; Park, Se-Hyung; Rios-Pilier, Jennifer; Perkins, Jordan T.; Welsh, William J.; Zhou, Changcheng

Book ID: 120507890
Publisher: Environmental Health Information Service
Year: 2012
Tongue: English
Weight: 722 KB
Volume: 120
Category: Article
ISSN: 0091-6765
DOI: 10.1289/ehp.1104426

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## Abstract Marked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450‐ and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (