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A Pharmacophore for Human Pregnane X Receptor Ligands

โœ Scribed by Ekins, S.


Book ID
118001034
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2002
Tongue
English
Weight
493 KB
Volume
30
Category
Article
ISSN
0090-9556

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## Abstract Marked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450โ€ and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (