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Bis(2-oxo-3-oxazolidinyl)phosphinic chloride (1) as a coupling reagent for N-alkyl amino acids

✍ Scribed by Tung, Roger D.; Rich, Daniel H.


Book ID
120514504
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
297 KB
Volume
107
Category
Article
ISSN
0002-7863

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N,N-bis[2-oxo-3-oxazolidinyl]phosphorodi
✍ S.B. Katti; K.L. Agarwal πŸ“‚ Article πŸ“… 1985 πŸ› Elsevier Science 🌐 French βš– 190 KB

Use of a rwel ccupliw reagent, N,N-bi$2-oxo-3-oxazolidinyllphosphorcdiamidic chloride (BUPCC) in the synthesis of oligc&.oxy~-ibonucleotides is described. This reagent allm the synthesis of phosphotriesters in high yields (70-m) without detectable side reactions. Synthesis of a hexanucleotide, d(A-A