✦ LIBER ✦

Bis(1,3-dihydroxy-isopropyl)amine (BDI) as an AB4 dendritic building block: rapid synthesis of a second generation dendrimer

✍ Scribed by David A Scott; Thomas M Krülle; Malcolm Finn; George W.J Fleet

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 145 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00487-1

No coin nor oath required. For personal study only.

✦ Synopsis

Bis(1,3-dihydroxy-isopropyl)amine (BDI) 1, a symmetrical AB 4 dendritic building block, is developed into two diamine linkers in which the nitrogen is more nucleophilic. The four primary alcohols in BDI undergo Michael reactions with t-butyl acrylate. Branch cells of this rare multiplicity allow the rapid construction of a second generation dendrimer 5 with 48 protected peripheral primary alcohol groups.

📜 SIMILAR VOLUMES

Synthesis of bis(1,3-dihydroxy-isopropyl

Synthesis of bis(1,3-dihydroxy-isopropyl)amine by reductive amination of dihydroxyacetone: Open chain equivalent of DMDP and a potential AB4 dendritic monomer

✍ David A. Scott; Thomas M. Krülle; Malcolm Finn; Robert J. Nash; Ana L. Winters; 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 290 KB

ChemInform Abstract: Synthesis of Bis(1,

ChemInform Abstract: Synthesis of Bis(1,3-dihydroxy-isopropyl)amine by Reductive Amination of Dihydroxyacetone: Open Chain Equivalent of DMDP and a Potential AB4 Dendritic Monomer.

✍ David A. Scott; Thomas M. Kruelle; Malcolm Finn; Robert J. Nash; Ana L. Winters; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB