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Bis-actinomycin D: A new synthetic sequence-specific ligand

✍ Scribed by M.V. Mikhailov; S.M. Nikitin; A.L. Zhuze; A.S. Zasedatelev; G.V. Gursky; B.P. Gottikh


Book ID
115912904
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
432 KB
Volume
136
Category
Article
ISSN
0014-5793

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A water-soluble phosphonate-functionalized phosphine ligand Na 2 [Ph 2 P(CH 2 ) 12 PO 3 ] (8), was prepared in eight steps from cyclododecanone. Phosphine 8 reacts with [Rh(COD)Cl] 2 in methanol to give the new complex Na 2 [Rh(COD)(Ph 2 P(CH 2 ) 12 PO 3 )Cl] (9). Complex 9 is inactive in the cataly