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Bipolar disorder: Evidence for a major locus

✍ Scribed by Spence, M. Anne ;Flodman, Pamela L. ;Sadovnick, A. Dessa ;Bailey-Wilson, Joan E. ;Ameli, Hossein ;Remick, Ronald A.


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
789 KB
Volume
60
Category
Article
ISSN
0148-7299

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Knowledge of the likely mode of inheritance of a disorder is useful for design of linkage studies, choice of mode of statistical analysis and estimation of power to detect disease genes. In their paper, "Bipolar Disorder: Evidence for a Major Locus," Spence et al. [1995] report complex segregation a

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Suggestive evidence of a locus on chromo
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## As part of a four-center NIMH Genetics Initiative on Bipolar Disorder, a genome screen using 365 markers was performed on 540 DNAs from 97 families, enriched for affected relative pairs. This is the largest uniformly ascertained and assessed linkage sample for this disease, and includes 232 subj