Knowledge of the likely mode of inheritance of a disorder is useful for design of linkage studies, choice of mode of statistical analysis and estimation of power to detect disease genes. In their paper, "Bipolar Disorder: Evidence for a Major Locus," Spence et al. [1995] report complex segregation a
Bipolar disorder: Evidence for a major locus
β Scribed by Spence, M. Anne ;Flodman, Pamela L. ;Sadovnick, A. Dessa ;Bailey-Wilson, Joan E. ;Ameli, Hossein ;Remick, Ronald A.
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 789 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0148-7299
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method (P = 0.001), an affected sib pair method (ESPA, P = 0.0008), and the transmission disequilibrium test (P = 0.024). These results suggest the presence of a susceptibility locus for bipolar disorder near the DAT locus on chromosome 5.
## As part of a four-center NIMH Genetics Initiative on Bipolar Disorder, a genome screen using 365 markers was performed on 540 DNAs from 97 families, enriched for affected relative pairs. This is the largest uniformly ascertained and assessed linkage sample for this disease, and includes 232 subj