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Biphasic elimination of noscapine

✍ Scribed by Milo Gibaldi; Norman D. Weiner

Publisher: John Wiley and Sons
Year: 1966
Tongue: English
Weight: 303 KB
Volume: 55
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600550804

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✦ Synopsis

OSCAPINE, an isoquinoline alkaloid of opium, N is an antitussive agent which depresses the medullary centers and suppresses the cough reflex. Pharmacological and clinical investigations have confirmed the value of noscapine as a potent nonaddictive cough suppressant (I).

Despite the antiquity of this opium derivative, little is known concerning its absorption, distribution, and elimination in the body. In 1961, Vedso (2) studied the absorption and excretion of noscapine in man. More recently, Nayak et al.

(3) investigated the rate of metabolism, urinary excretion, and organ distribution of noscapine in

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