Novel biphasic synthesis of porphyrin

✍ Scribed by Paul E. Ellis Jr; Wayne A. Langdale

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 28 KB
• Volume: 01
• Category: Article
• ISSN: 1088-4246
• DOI: 10.1002/(sici)1099-1409(199707)1:3<305::aid-jpp27>3.0.co;2-q

✦ Synopsis

An unusual synthesis of porphyrin has been developed using a novel biphasic solvent system. Under optimized conditions reproducible yields of pure porphyrin of over 15% can be easily obtained in about two hours from the acid-catalysed condensation of 2-hydroxymethylpyrrole in a solvent consisting of water and an immiscible ketone. Important variables of the reaction have been studied to improve the yield and characterize the limitations of the reaction.