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Biotransformation rate (in vitro) and systemic potency (in vivo) of the topical glucocorticoid budesonide in male and female rats

✍ Scribed by Paul Andersson; Ralph Brattsand; Staffan Edsbäcker; Leif Källström; Åke Ryrfeldt


Book ID
116003030
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
449 KB
Volume
17
Category
Article
ISSN
0022-4731

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✍ Anat Biegon; David Samuel 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 483 KB

The accumulation of IP injected 3H-desipramine (DMI) in the brain and in the liver has been studied in both male and female rats. The total amount of DMI in the brains of females is 2 to 4 times that found in the brains of males. In females the amount of DMI is highest on the day of estrus and lowes