Biotransformation of nitriles to hydroxamic acids via a nitrile hydratase–amidase cascade reaction
✍ Scribed by Vojtěch Vejvoda; Ludmila Martínková; Alicja B. Veselá; Ondřej Kaplan; Sabine Lutz-Wahl; Lutz Fischer; Bronislava Uhnáková
- Book ID
- 113804832
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 172 KB
- Volume
- 71
- Category
- Article
- ISSN
- 1381-1177
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A number of novel N-protected b-amino nitriles were prepared as substrates for two nitrile-converting microorganisms, Rhodococcus sp. R312 and Rhodococcus erythropolis NCIMB 11540. The respective biotransformation products, b-amino acids, are known to be pharmacological very potent compounds.