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Biotransformation of isosorbide dinitrate in humans

✍ Scribed by W. H. Down; L. F. Chasseaud; R. K. Grundy


Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
274 KB
Volume
63
Category
Article
ISSN
0022-3549

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## Abstract Plasma concentrations of isosorbide dinitrate have been measured after intravenous infusion of drug at a rate of 5Β·0 mg h^βˆ’1^ for 150 min and after single equal oral doses of 12Β·5 mg of drug in solution to two normal human subjects. During the infusion, uneven plateau concentrations wer

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A selective and sensitive capillary column gas-liquid chromatographic procedure has been developed for the simultaneous determination of isosorbide dinitrate (ISDN) and its mononitrate metabolites in rabbit blood and tissue homogenates. The method has a limit of detection of O.lng ml-l for ISDN, l n