## Abstract Plasma concentrations of isosorbide dinitrate have been measured after intravenous infusion of drug at a rate of 5Β·0 mg h^β1^ for 150 min and after single equal oral doses of 12Β·5 mg of drug in solution to two normal human subjects. During the infusion, uneven plateau concentrations wer
Biotransformation of isosorbide dinitrate in humans
β Scribed by W. H. Down; L. F. Chasseaud; R. K. Grundy
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 274 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3549
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## Abstract Concentrations of the vasodilator isosorbide dinitrate (ISDN) in human plasma can be measured with good sensitivity (about 0Β·2β0Β·5 ng ml^β1^) using electronβcapture gas chromatography after a oneβstage extraction. The mean recovery of ISDN from plasma was 83 per cent Β± 9 standard deviat
A selective and sensitive capillary column gas-liquid chromatographic procedure has been developed for the simultaneous determination of isosorbide dinitrate (ISDN) and its mononitrate metabolites in rabbit blood and tissue homogenates. The method has a limit of detection of O.lng ml-l for ISDN, l n