Biotransformation of amitriptyline in alcoholic depressive patients
β Scribed by M. Sandoz; S. Vandel; B. Vandel; B. Bonin; G. Allers; R. Volmat
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 651 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
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## Abstract ## Objective Studies indicate that serotoninergic and noradrenergic pathophysiological mechanisms may underlie both alcohol abuse/dependence and depressive disorder. The purpose of this study was to evaluate and compare the effectiveness and tolerability of two serotonergic and noradre
Thirteen elderly depressed patients (age 60-82 years) were treated for 5 weeks with a fixed dose of amitriptyline 100 mg (sustained release preparation). In all patients the sum of concentrations of amitriptyline and nortriptyline exceeded 130 gg/1, which is the recommended plasma level. Cardiovascu
The antidepressant efficacy and adverse-effects of rolipram (a dialkoxyphenyl-2-pyrrolidone) were compared to those of amitriptyline in the treatment of depressive illness requiring hospital admission in a double-blind study. Fifty patients meeting DSM-III criteria for Major Depression whose scores