✦ LIBER ✦

In-patient major depression: is rolipram as effective as amitriptyline?

✍ Scribed by A. I. F. Scott; A. F. Perini; P. A. Shering; L. J. Whalley

Publisher: Springer
Year: 1991
Tongue: English
Weight: 321 KB
Volume: 40
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00280065

No coin nor oath required. For personal study only.

✦ Synopsis

The antidepressant efficacy and adverse-effects of rolipram (a dialkoxyphenyl-2-pyrrolidone) were compared to those of amitriptyline in the treatment of depressive illness requiring hospital admission in a double-blind study. Fifty patients meeting DSM-III criteria for Major Depression whose scores on the Hamilton Rating Scale for Depression (HRSD) remained above 17 after 5 to 7 days on placebo were randomly allocated to either treatment. The rate of recovery in those patients treated by amitriptyline was substantially greater than in those patients treated by rolipram. Twice as many patients dropped out of treatment by rolipram because of lack of efficacy or adverse-effects compared with patients treated by amitriptyline. Rolipram produced fewer adverse-effects attributable to cholinergic blockade, but more nausea. We conclude that amitriptyline is more effective than rolipram in the treatment of depressed hospital in-patients.

📜 SIMILAR VOLUMES

Major depression as a risk factor for ea

Major depression as a risk factor for early institutionalization of dementia patients living in the community

✍ Pascale Dorenlot; Marc Harboun; Vincent Bige; Jean-Claude Henrard; Joël Ankri 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 88 KB 👁 2 views

## Abstract ## Objective Although depression is known to be frequently associated with dementia, it is nonetheless under‐diagnosed and under‐treated among this patient population. Its effect on outcome for dementia patients is thought to be substantial, because depression appears to induce higher

Decreased striatal D1 binding as measure

Decreased striatal D1 binding as measured using PET and [11C]SCH 23,390 in patients with major depression with anger attacks

✍ Darin D. Dougherty; Ali A. Bonab; William E. Ottowitz; Eli Livni; Nathaniel M. A 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB

Long-term treatment with moclobemide. An

Long-term treatment with moclobemide. An open-label, non-comparative, multiple-distributed study in patients with a major depressive episode as defined by DSM-III

✍ E. Moll; M. Stabl; R. Wegscheider; R. Amrein 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 297 KB

Is cardiovascular MRI equally effective

Is cardiovascular MRI equally effective as TEE in evaluation of left atrial appendage thrombus in patients with atrial fibrillation undergoing pulmonary vein isolation

✍ Sandeep Anreddy; Sukhraj Balhan; June A Yamrozik; Ronald B Williams; Mark Doyle; 📂 Article 📅 2011 🏛 BioMed Central 🌐 English ⚖ 182 KB

Reduced number of red blood cells, lower

Reduced number of red blood cells, lowered hematocrit and hemoglobin, and increased number of reticulocytes in major depression as indicators of activation of the inflammatory response system: effects of antidepressant drugs

✍ Erik Vandoolaeghe; Nathalie De Vos; Paul Demedts; Annick Wauters; Hugo Neels; Pi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 107 KB 👁 2 views

There is some evidence that major depression is characterized by an activation of the in¯ammatory response system (IRS). Activation of the IRS and major depression are accompanied by changes in the erythron, such as a lowered number of red blood cells (RBC), lowered hematocrit (Hct), and hemoglobin

A higher degree of criticism about the e

A higher degree of criticism about the effectiveness of bosentan for digital ulcers in scleroderma patients, as for interstitial disease, is also necessary: Comment on the article by Seibold et al

✍ Markus Bredemeier 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 43 KB 👁 3 views