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Biotinylated recombinant interleukin-2 a tool for research on the interleukin-2 receptor

✍ Scribed by Brian M.J. Foxwell; David Taylor; Brigitte Greiner; Mike J. Mihatsch; Vesna Olivieri; Bernhard Ryffel

Book ID: 118901473
Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 30 KB
Volume: 117
Category: Article
ISSN: 0022-1759
DOI: 10.1016/0022-1759(89)90130-0

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## Abstract DAB~486~IL‐2 is a genetically engineered fusion protein consisting of a portion of diphtheria toxin fused to human IL‐2. It is specifically cytotoxic for tumor cells which bear high‐affinity IL‐2 receptors (IL‐2R). DAB~389~IL‐2 is a similarly constructed hybrid protein which is smaller