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Interleukin-2 fusion protein: An investigational therapy for interleukin-2 receptor expressing malignancies

✍ Scribed by J. Nichols; F. Foss; T.M. Kuzel; C.F. LeMaistre; L. Platanias; M.J. Ratain; A. Rook; M. Saleh; G. Schwartz

Book ID
117663587
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
351 KB
Volume
33
Category
Article
ISSN
0959-8049

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## Abstract DAB~486~IL‐2 is a genetically engineered fusion protein consisting of a portion of diphtheria toxin fused to human IL‐2. It is specifically cytotoxic for tumor cells which bear high‐affinity IL‐2 receptors (IL‐2R). DAB~389~IL‐2 is a similarly constructed hybrid protein which is smaller