The diterpenoid moiety of brasilicardin A (1), isolated from the actinomycete Nocardia brasiliensis IFM 0406, was shown to be biosynthesized from D-glucose via the non-mevalonate pathway.
β¦ LIBER β¦
Biosynthesis of the monoterpenoid moiety of teleocidins via the non-mevalonate pathway in Streptomyces
β Scribed by Kazuhiro Irie; Yu Nakagawa; Satoru Tomimatsu; Hajime Ohigashi
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 136 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The monoterpenoid moiety of teleocidin B-4 was shown to be biosynthesized from D-glucose v/a the nonmevalonate pathway proposed by Rohmer et al. using Streptomyces blastmyceticum NA34-17.
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## Abstract The enzymes of the nonβmevalonate pathway for isoprenoid biosynthesis are attractive targets for the development of novel drugs against malaria and tuberculosis. This pathway is used exclusively by the corresponding pathogens, but not by humans. A series of waterβsoluble, cytidineβbased