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Biosynthesis of Squalene. Evidence for a Tertiary Cyclopropylcarbinyl Cationic Intermediate in the Rearrangement of Presqualene Diphosphate to Squalene

โœ Scribed by Jarstfer, Michael B.; Blagg, Brian S. J.; Rogers, Daniel H.; Poulter, C. Dale


Book ID
127318548
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
112 KB
Volume
118
Category
Article
ISSN
0002-7863

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Recently a new intermediate in the biosynthesis of squalene has been obtained from farnesyl pyrophosphate as substrate in a yeast homogenate containing minimal amounts of reduced nicotinamide adenine di-'nucleotide (NADP-H) (1). On the basis of a number of experimental results, structure I was sugge